Wrinkle Shot Serum

Contains the First Wrinkle-Improving Quasi-Drug Active Ingredient NEI-L1 Approved in Japan.

First Quasi-Drug Active Ingredient (approved July 2016)

Wrinkle Shot Serum contains the NEI-L1, the first wrinkle-improving quasi-drug active ingredient (approved July 2016).
NEI-L1 penetrates through to the skin’s dermis to improve wrinkles.

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NEI-L1 is a quasi-drug active ingredient that POLA originally developed after searching through around 5,400 types of ingredients.

The quasi-drug active ingredient NEI-L1 inhibits the activity of neutrophil elastase.
NEI-L1 comprises four amino-acid derivatives that work to inhibit the activity of neutrophil elastase, and improve wrinkles.
It improves wrinkles by adjusting the balance of production and reduction of the dermis components.

Quasi-Drug Active Ingredient that Penetrates Through to the Dermis — “NEI-L1 Dermal-Penetration Formula”

The quasi-drug active ingredient NEI-L1 works well with water.
So we’ve developed a “NEI-L1 dermis permeation formulation”, which doesn’t use any water.
This quasi-drug active ingredient penetrates through to the dermis and attaches to the skin, using its moisture content to improve wrinkles.

WRS Serum

Contains Two New Liquid Ingredients Based on New Scientific Discoveries. Motion Skin Veil is a Formula That Enhances Both Firmness and Suppleness.

With WRS Serum, POLA focused on the facial expression pressure applied to the skin by facial movements.
The formula is designed to alleviate this pressure.

Containing Motion S Liquid*4, which focuses on the skin’s suppleness, and NERE Liquid*5, which supports smooth skin movements, the formula creates a film for increased firmness and suppleness to make your skin (stratum corneum) smoothly contour to your facial movements.

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  1. Wrinkle improvement: Recognized as achieving a significant change in wrinkle improvement in the Wrinkle Grade evaluation standard listed in the Japanese Cosmetic Science Society’s “Guidelines for Evaluation of Anti-Wrinkle Products” for the approval of new functions.
  2. NEI-L1: Ingredient name - Sodium [[trifluoro-isopropyl-oxopropyl] aminocarbonyl] pyrrolidinyl] carbonyl] -methylpropyl] aminocarbonyl] benzoylamino] acetate
  3. Skin: Stratum corneum
  4. Motion S Liquid: POLA’s original mixed ingredient that includes dipotassium glycyrrhizate as an active ingredient for protecting against skin irritation, and Geranium thunbergii extract, Sanguisorba officinalis root extract, Swertia herb extract, and benzyl ursolate as moisturizing ingredients
  5. NERE Liquid: Oil-soluble Prunus persica leaf extract, Field horsetail extract, and cyclohexylglycerin (moisturizing ingredients)

* Anti-aging care: Skin care using cosmetics suited to your age